Dopamine is known as the feel-good neurotransmitter—a chemical that ferries information between neurons. The brain releases it when we eat food that we crave or while we have sex , contributing to feelings of pleasure and satisfaction as part of the reward system. This important neurochemical boosts mood, motivation , and attention , and helps regulate movement, learning, and emotional responses.
Psychiatric and Neurodegenerative Disorders
Swedish pharmacologist and neuroscientist Arvid Carlsson won the Nobel prize in 2000 for his research on dopamine, showing its importance in brain function. He helped show that the neurotransmitter is heavily involved in the motor system. When the brain fails to produce enough dopamine, it can result in Parkinson’s disease. The primary treatment for Parkinson’s disease is a drug called L-dopa, which spurs the production of dopamine.
Dopamine has also been implicated in schizophrenia and ADHD ; the brain systems underlying these conditions (as well as substance abuse disorder) are complex. The activity of the dopamine system depends on the state of one’s dopamine receptors, and in people with these conditions, the chemical interacts with other factors in ways that have yet to be explained.
It is no exaggeration to say that dopamine makes us human. Beginning in infant development, dopamine levels are critical, and mental disabilities can arise if dopamine is not present in sufficient quantities. Dopamine is implicated in genetic conditions like congenital hypothyroidism. Dopamine deficiency is also implicated in other conditions such as Alzheimer's, depressive disorders, binge-eating, addiction, and gambling.
Drugs currently used to treat ADHD do indeed increase the effectiveness of dopamine. This helps patients with ADHD focus and pay better attention to one thing at a time. How exactly more dopamine translates into better concentration and focus is not yet understood.
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