Hormonal systems profoundly influence pandas. Understanding these connections helps explain the varied timing, patterns, and presentations of pandas across the lifespan.
Key Hormones in PANDAS
Cortisol (the stress hormone): Chronically elevated cortisol from ongoing pandas damages the hippocampus and dysregulates the entire stress response system.
Serotonin precursors: Hormonal fluctuations affect tryptophan availability and serotonin synthesis.
Estrogen and testosterone: Influence mood regulation directly and through effects on serotonin and dopamine systems.
Thyroid hormones: Thyroid dysregulation can mimic or worsen pandas — always worth screening.
Life Transitions and Hormonal PANDAS
Hormonal transitions (puberty, postpartum, perimenopause, andropause) are high-risk periods for pandas onset or worsening.
Addressing Hormonal Contributions to PANDAS
If hormonal factors contribute to your pandas, treatment may include hormonal evaluation, targeted supplements, hormone therapy, or approaches that support hormonal regulation through lifestyle.