Hormonal systems profoundly influence migraine. Understanding these connections helps explain the varied timing, patterns, and presentations of migraine across the lifespan.
Key Hormones in Migraine
Cortisol (the stress hormone): Chronically elevated cortisol from ongoing migraine damages the hippocampus and dysregulates the entire stress response system.
Serotonin precursors: Hormonal fluctuations affect tryptophan availability and serotonin synthesis.
Estrogen and testosterone: Influence mood regulation directly and through effects on serotonin and dopamine systems.
Thyroid hormones: Thyroid dysregulation can mimic or worsen migraine — always worth screening.
Life Transitions and Hormonal Migraine
Hormonal transitions (puberty, postpartum, perimenopause, andropause) are high-risk periods for migraine onset or worsening.
Addressing Hormonal Contributions to Migraine
If hormonal factors contribute to your migraine, treatment may include hormonal evaluation, targeted supplements, hormone therapy, or approaches that support hormonal regulation through lifestyle.